 |
| Drugs |
One dose of morphine was found lowered barriers in mice, even after the drug was missing from their system, according to the findings that may help scientists to better understand addiction in humans, U.S. researchers said on Wednesday.
In mice, these painkillers inhibit the brain's ability to strengthen connections or synapses, which erode the prizes or pleasure, said the researchers from Brown University in the journal Nature.
"What we found is that synapses barrier can no longer be strengthened 24 hours after treatment with morphine, which suggests that a natural brake has been lost," said Julie Kauer, a professor of molecular Pharmacology, physiology and biotechnology at Brown University.
"This happened 24 hours after the animals were given a single dose of morphine and even though there was no morphine left in the brain. It shows that it is a continuous effect of these drugs," Kauer said in an interview.
Kauer said the findings provide additional evidence on a set of increases and shows the relationship between learning and addiction and may help in the development of drugs to treat people who are addicted.
"Strengthening synapses, we think, is the beginning of the formation of memories," he said.
By closing the natural ability to strengthen relationships that hinder pleasure, the brain may begin to learn to feel hungry for drugs, "he said.
Kauer said the brain has two types of nerves, nerves which evoke the relationship of nerves and nerve that inhibit or suppress it.
"If the barrier decreases, you lose the stimulus," he said.
Imbalances that may encourage the burning of nerves that make dopamine (the pleasure chemical) in the brain that is activated after giving gifts to experience such as eating, sex and drug use resulting in addiction.
Kauer found small changes in one part of the midbrain, are involved in the award system. Although studies examining the causes of drug addiction initial reaction, he intends to study the impact of these one day.
0 Comments:
Post a Comment